Artigos de referência sobre microbioma e saúde


MICROBIOMA HUMANO: INTRODUÇÃO

The Human Microbiome and the Future Practice of Medicine. Relman D.A. JAMA. 2015 Sep 15;314(11):1127-8. doi: 10.1001/jama.2015.10700.

Gut microbiota in 2016: A banner year for gut microbiota research. Wendy S. Garrett. NATURE REVIEWS Gastroenterology & Hepatology 14, 78-80 (2017) / doi: 10.1038/nrgastro.2016.207. Published online 11 January 2017.

Living in a microbe’s world. Jonathan Blott. THE LANCET Gastroenterology & Hepatology  January 2017 / doi:http://dx.doi.org/10.1016/S2468-1253(16)30185-6.

Microbes and the gut-brain axis. Christina Wayman. THE LANCET Gastroenterology & Hepatology  November 2016 / doi:http://dx.doi.org/10.1016/S2468-1253(16)30124-8.

Analysis  – Time to consider the risks of caesarean delivery for long term child health. Jan Blustein & Jianmeng Liu. BMJ 2015; 350. doi: 10.1136/bmj.h2410 (Published 10 June 2015).

The Human intestinal microbiome in health and disease. Susan V. Lynch, Ph.D., and Oluf Pedersen, M.D., D.M.Sc.. N Engl J Med 2016;375:2369-79.  DOI: 10.1056/NEJMra1600266.

Influence of diet on the gut microbiome and implications for human health. Rasnik K. Singh. Journal of Translational Medicine201715:73. DOI: 10.1186/s12967-017-1175-y.

Sex, Body Mass Index, and Dietary Fiber Intake Influence the Human Gut Microbiome. Christine Dominianni,1 Rashmi Sinha,3 James J. Goedert,3 Zhiheng Pei,2,4,5,6 Liying Yang,6 Richard B. Hayes,1,2 and Jiyoung Ahn1,2,. PLoS One. 2015; 10(4): e0124599.  Published online 2015 Apr 15. doi: 10.1371/journal.pone.0124599    PMCID: PMC4398427.

Analysis of the microbiome: Advantages of whole genome shotgun versus 16S amplicon sequencing. Ranjan R1, Rani A2, Metwally A3, McGee HS4, Perkins DL5.Biochem Biophys Res Commun. 2016 Jan 22;469(4):967-77. doi: 10.1016/j.bbrc.2015.12.083. Epub 2015 Dec 22.

Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population. Alexander Koliada. BMC MicrobiologyBMC series -inclusive and trusted201717:120. https://doi.org/10.1186/s12866-017-1027-1.

Comparative analysis of gut microbiota associated with body mass index in a large Korean cohort. Yeojun Yun†, Han-Na Kim†, Song E. Kim, Seong Gu Heo. BMC Microbiology. BMC series –  inclusive and trusted201717:151. DOI: 10.1186/s12866-017-1052-0.

Strains, functions and dynamics in the expanded Human Microbiome Project. Jason Lloyd-Price, Anup Mahurkar, Gholamali Rahnavard, Jonathan Crabtree, Joshua Orvis. Nature  (2017)    doi:10.1038/nature23889.


OBESIDADE E MICROBIOMA

Health Effects of Overweight and Obesity in 195 Countries over 25 Years. The GBD 2015 Obesity Collaborators. N Engl J Med 2017; 377:13-27July 6, 2017DOI: 10.1056/NEJMoa1614362.

Gut microbiome diversity and high-fibre intake are related to lower long-term weight gain. C Menni, M A Jackson. International Journal of Obesity (2017) 41, 1099–1105; doi:10.1038/ijo.2017.66; published online 4 April 2017.

Intestinal Microbiota Is Influenced by Gender and Body Mass Index. Carmen Haro,  Oriol A. Rangel-Zúñiga. Published: May 26, 2016. https://doi.org/10.1371/journal.pone.0154090.

Burning fat by bugging the system. Evan D. Rosen . N Engl J Med 2016; 374:885-887/ March3, 2016/ DOI: 10.1056/NEJMcibr1515457.

The Microbiome and Risk for Obesity and Diabetes. Anthony L.Komaroff. http://jama.jamanetwork.com/ on 12/22/2016.

An obesity-associated gut microbiome with increased capacity for energy harvest.Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. Nature. 2006; 444(7122):1027-1031.

The human gut microbiome and body metabolism: implications for obesity and diabetes. Devaraj S, Hemarajata P, Versalovic J. Clin Chem. 2013;59(4):617-628.

Human genetic variation and the gut microbiome in disease.Andrew Brantley Hall, Andrew C. Tolonen & Ramnik J. XavierNature.Reviews Genetics (2017)  doi:10.1038/nrg.2017.63   Published online, 21 August 2017.


DIABETES E MICROBIOMA

MetaHIT Consortium. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Forslund K, Hildebrand F, Nielsen T, et al; Nature. 2015;528(7581):262-266.

The Influence of the Microbiome on Type 1 Diabetes. A Paun et al. J Immunol 198 (2), 590-595. 2017 Jan 15. DOI: 10.4049/jimmunol.1601519.

Changes to the gut microbiome that are associated with type 2 diabetes. From Metagenome-wide association studies: fine-mining the microbiome.Jun Wang & Huijue Jia. Nature Reviews Microbiology 14, 508–522(2016). doi:10.1038/nrmicro.2016.83.

Human gut microbes impact host serum metabolome and insulin sensitivity.Helle Krogh Pedersen. Nature 535,     376–381 (21 July 2016)  doi:10.1038/nature18646.

The role of the intestinal microbiota in type 1 diabetes mellitus.Mikael Knip & Heli Siljander. Nature Reviews Endocrinology 12,154–167   (2016). doi:10.1038/nrendo.2015.218.

The gut microbiome as a target for prevention and treatment of hyperglycaemia in type 2 diabetes: from current human evidence to future possibilities. Louise BrunkwallMarju Orho-Melander. Diabetologia  June 2017, Volume 60, Issue 6, pp 943–951, doi:10.1007/s00125-017-4278-3.

Diabetes and the Microbiome. Clay F. Semenkovich, Jayne Danska, Tamara Darsow. Diabetes. American Diabetes Association and JDRF Research Symposium: 13 August 2015 Diabetes and the Microbiome  DOI: 10.2337/db15-0597.

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future.Kahn SE1, Cooper ME2, Del Prato S3.Lancet. 2014 Mar 22;383(9922):1068-83. doi: 10.1016/S0140-6736(13)62154-6. Epub 2013 Dec 3.


DOENÇAS INTESTINAIS INFLAMATÓRIAS

Dynamics of the human gut microbiome in inflammatory bowel disease. Jonas Halfvarson. Nature Microbiology 2, Article number: 17004 (2017) doi:10.1038/nmicrobiol.2017.4.

The gut microbiota and inflammatory bowel disease. Katsuyoshi Matsuoka and Takanori Kanai. Semin Immunopathol. 2015; 37: 47–55. Published online 2014 Nov 25. doi:  10.1007/s00281-014-0454-4.

The Microbiome in Inflammatory Bowel Diseases: Current Status and the Future Ahead.Aleksandar D. Kostic. Gastroenterology. 2014 May; 146(6): 1489–1499.  doi:  10.1053/j.gastro.2014.02.009.

Regulation of inflammation by microbiota interactions with the host. J Magarian Blander. Nature Immunology 18,851–860 (2017)    doi:10.1038/ni.3780.

Gut microbiota and IBD: causation or correlation? Josephine Ni. Nature Reviews Gastroenterology & Hepatology (2017) doi:10.1038/nrgastro.2017.88.

Understanding and preventing the global increase of inflammatory bowel disease.Kaplan, G. G. & Ng, S. C.Gastroenterology 152, 313–321.e2 (2017).

Host microbiome signature of Crohn’s disease.Brooke LaFlamme. Nature Genetics  46,811  (2014)    doi:10.1038/ng.3055.

Diagnosing IBD with the gut microbiome. Iain Dickson. Nature Reviews Gastroenterology & Hepatology 14,195 (2017)    doi:10.1038/nrgastro.2017.25.


MICROBIOMA HUMANO E TRANSPLANTE FECAL

Understanding the mechanisms of faecal microbiota transplantation. Alexander Khoruts & Michael J. Sadowsky. Nature Reviews Gastroenterology & Hepatology 13,508–516 (2016). doi:10.1038/nrgastro.2016.98.

Burden of Clostridium difficile infection in the United States.Lessa FC. N Engl J Med. 2015 Feb 26;372(9):825-34. doi: 10.1056/NEJMoa1408913.

Multiple fresh fecal microbiota transplants induces and maintains clinical remission in Crohn’s disease complicated with inflammatory mass. Zhi He, Pan Li, Jianguo Zhu. Scientific Reports 7, Article number: 4753 (2017) doi:10.1038/s41598-017-04984-z.

Fecal microbiota transplantation in children: a brief review. Suchitra K. Hourigan & Maria Oliva-Hemker. Pediatric Research (2016) doi:10.1038/pr.2016.48.

Fecal Microbiota Transplantation for the Management of Clostridium difficile Infection. Krishna Rao.Infect Dis Clin North Am. 2015 Mar; 29(1): 109–122. doi:10.1016/j.idc.2014.11.009.

The New Era of Treatment for Obesity and Metabolic Disorders: Evidence and Expectations for Gut Microbiome Transplantation. Thilini N. Jayasinghe. Front Cell Infect Microbiol. 2016; 6: 15. Published online 2016 Feb 19. doi: 10.3389/fcimb.2016.00015.


INFECÇÕES

Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome. Robert P. Dickson. Nature Microbiology 1, Article number: 16113 (2016) doi:10.1038/nmicrobiol.2016.113.

The role of the gut microbiota in sepsis. Bastiaan W Haak, MD, Dr W Joost Wiersinga, MD. The Lancet Gastroenterology & Heptaology. DOI: http://dx.doi.org/10.1016/S2468-1253(16)30119-4.

The immunopathology of sepsis and potential therapeutic targets.Tom van der Poll, Frank L. van de Veerdonk, Brendon P. Scicluna & Mihai G. Netea. Nature Reviews Immunology 17,407–420 (2017) doi:10.1038/nri.2017.36.

Enteric immunity, the gut microbiome, and sepsis: Rethinking the germ theory of disease. Javier Cabrera-Perez. Exp Biol Med (Maywood). 2017 Jan; 242(2): 127–139. Published online 2016 Sep 15. doi:  10.1177/1535370216669610.

Lung microbiome in human immunodeficiency virus infection. Twigg HL, Weinstock, Knox. Transl Res. 2017 Jan;179:97-107. doi: 10.1016/j.trsl.2016.07.008. Epub 2016 Jul 18.

The gut microbiome in human immunodeficiency virus infection.Gili Zilberman-Schapira. BMC Med. 2016; 14: 83. Published online 2016 Jun 3. doi:10.1186/s12916-016-0625-3.


NEOPLASIAS

The Human Microbiome and Cancer. Rajagopala SV, Vashee S. Cancer Prev Res (Phila). 2017 Apr;10(4):226-234. doi: 10.1158/1940-6207.CAPR-16-0249. Epub 2017 Jan 17.

Microbiota: a key orchestrator of cancer therapy. Soumen Roy& Giorgio Trinchieri. Nature Reviews Cancer  17,271–285  (2017) doi:10.1038/nrc.2017.13.

Anticancer effects of the microbiome and its products. Laurence Zitvogel. Nature Reviews Microbiology 15,465–478 (2017) doi:10.1038/nrmicro.2017.44.

Epidemiologic studies of the human microbiome and cancer. Emily Vogtmann and James J Goedert. Br J Cancer. 2016 Feb 2; 114(3): 237–242.  doi:  10.1038/bjc.2015.465.

Gut microbiota imbalance and colorectal cancer. Johan Gagnière, Jennifer Raisch, Julie Veziant, Nicolas Barnich, Richard Bonnet, Emmanuel Buc, Marie-Agnès Bringer, Denis Pezet, and Mathilde Bonnet. World J Gastroenterol. 2016 Jan 14; 22(2): 501–518. Published online 2016 Jan 14. doi:  10.3748/wjg.v22.i2.501.

The gut microbiota and gastrointestinal surgery. Kristina Guyton   & John C. Alverdy. Nature Reviews Gastroenterology & Hepatology 14,43–54(2017)   doi:10.1038/nrgastro.2016.139.

Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases. Bidisha Paul, Stephen Barnes, Wendy Demark-Wahnefried, Casey Morrow, Carolina Salvador, Christine Skibola, and Trygve. Clin Epigenetics. 2015; 7: 112.  doi:  10.1186/s13148-015-0144-7.

Review of the gut microbiome and esophageal cancer: Pathogenesis and potential clinical implications. Yoshifumi Baba.AGS Volume 1, Issue 2 June 2017 Pages 99–104   DOI: 10.1002/ags3.12014.

Gut microbiota modulation of chemotherapy efficacy and toxicity. James L. Alexander, Ian D. Wilson, Julian Teare, Julian R. Marchesi, Jeremy K. Nicholson & James M. Kinross. Nature Reviews Gastroenterology & Hepatology 14, 356–365 (2017)  doi:10.1038/nrgastro.2017.20.

Hallmarks of response to immune checkpoint blockade. Alexandria P Cogdill, Miles C Andrews and Jennifer A Wargo. British Journal of Cancer (2017) 117, 1–7. doi:10.1038/bjc.2017.136. Published online 18 May 2017.

Gut Microbiome Correlates With Response to Immunotherapy in Metastatic Melanoma. Vancheswaran Gopalakrishnan, Christine Spencer, Alexandre Reuben. Study presented at the 2017 American Society of Clinical Oncology Annual Meeting.


PACIENTES CRÍTICOS

Extreme Dysbiosis of the Microbiome in Critical Illness. Daniel McDonald, Gail Ackermann, Ludmila Khailova, Christine Baird, Daren Heyland, Rosemary Kozar, Margot Lemieux, Karrie Derenski, Judy King, Christine Vis-Kampen, Rob Knight, Paul E. Wischmeyer. AMS JOURNALS. DOI: 10.1128/mSphere.00199-16.

Role of the microbiome, probiotics, and ‘dysbiosis therapy’ in critical illness. Paul E. Wischmeyer,a Daniel McDonald,b and Rob Knight. Curr Opin Crit Care. 2016 Aug; 22(4): 347–353. doi:  10.1097/MCC.0000000000000321.

The microbiome and critical illness. Robert P Dickson, MD. Lancet Respir Med. 2016 Jan; 4(1): 59–72. doi:  10.1016/S2213-2600(15)00427-0.


SINDROME METABÓLICAS.

Gut microbiome and metabolic syndrome. Mazidi M, Rezaie P, Kengne AP, Mobarhan MG, Ferns GA. Diabetes Metab Syndr. 2016 Apr-Jun;10(2 Suppl 1):S150-7. doi: 10.1016/j.dsx.2016.01.024. Epub 2016 Feb 11.

The Influence of the Gut Microbiome on Obesity, Metabolic Syndrome and Gastrointestinal Disease. Parth J Parekh, Luis A Balart and David A Johnson. Clinical and Translational Gastroenterology (2015) 6, e91; doi:10.1038/ctg.2015.16. Published online 18 June 2015.

Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Boulangé CL, Neves AL, Chilloux J, Nicholson JK, Dumas ME. Genome Med. 2016 Apr 20;8(1):42. doi: 10.1186/s13073-016-0303-2.

Understanding the role of gut microbiome in metabolic disease risk. Yolanda Sanz, Marta Olivares, Ángela Moya-Pérez and Carlo Agostoni. Pediatric Research  (2015)  77, 236–244    doi:10.1038/pr.2014.170.

The microbiome in celiac disease: Beyond diet-genetic interactions. Jose U. Scher. Cleveland Clinic Journal of Medicine. 2016 March;83(3):228-230.


ALERGIAS E DOENÇAS DA PELE

The balance of metagenomic elements shapes the skin microbiome in acne and health. Emma Barnard, Baochen Shi, Dezhi Kang, Noah Craft & Huiying Li. Scientific Reports 6, Article number: 39491 (2016) doi:10.1038/srep39491.

Skin microbiome and acne vulgaris: Staphylococcus, a new actor in acne. Dreno B, Martin R, Moyal D, Henley JB, Khammari A, Seité S.

Exp Dermatol. 2017 Sep;26(9):798-803. doi: 10.1111/exd.13296. Epub 2017 Apr 10.

The skin microbiome in acne—Staphylococcus, a new player in acne management. Sophie Seite, PhD, La Roche-Posay; Dominique Moyal, PhD, La Roche-Posay; Brigitte Dreno, MD, CHU Nantes; Amir Khammari, CHU Nantes; Richard Martin, MS, L’Oreal.

JAAD June 2017Volume 76, Issue 6, Supplement 1, Page AB256. DOI: http://dx.doi.org/10.1016/j.jaad.2017.04.997. Microbial biofilms and the human skin microbiome. Michael Brandwein, Doron Steinberg & Shiri Meshner.NPJ Biofilms and Microbiomes 2, Article number: 3 (2016). doi:10.1038/s41522-016-0004-z.

Unexplored diversity and strain-level structure of the skin microbiome associated with psoriasis. Adrian Tett, Edoardo Pasolli, Stefania Farina, Duy Tin Truong, Francesco Asnicar, Moreno Zolfo. NPJ Biofilms and Microbiomes 3, Article number: 14 (2017). doi:10.1038/s41522-017-0022-5.

The influence of skin microorganisms on cutaneous immunity. Yasmine Belkaid& Samira Tamoutounour. Nature Reviews Immunology 16,353–366 (2016) doi:10.1038/nri.2016.48.

Microbiomic Signatures of Psoriasis: Feasibility and Methodology Comparison. Alexander Statnikov, Alexander V. Alekseyenko, Zhiguo Li, Mikael Henaff, Guillermo I. Perez-Perez. Scientific Reports 3, Article number: 2620 (2013) doi:10.1038/srep02620.

The role of the skin microbiome in atopic dermatitis. Williams MR, Gallo RL.Curr Allergy Asthma Rep. 2015 Nov;15(11):65. doi: 10.1007/s11882-015-0567-4.

The microbiome in allergic disease: Current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology.

Yvonne J. Huang, MD , Benjamin J. Marsland, PhD, Supinda Bunyavanich, MD, MPH, MPhil, Liam O’Mahony. Journal of Allergy Clinical and Immunology – April 2017 Volume 139, Issue 4, Pages 1099–1110 DOI: http://dx.doi.org/10.1016/j.jaci.2017.02.007.


MICROBIOMA E OFTALMOLOGIA

Association of the Intestinal Microbiome with the Development of Neovascular Age-Related Macular Degeneration. Martin S. Zinkernagel. Scientific Reports 7, Article number: 40826 (2017) doi:10.1038/srep40826.

Changes in the Eye Microbiota Associated with Contact Lens Wearing. Hakdong Shin et al. mBio, March 2016 DOI: 10.1128/mBio.00198-16.

Human Microbiota and Ophthalmic Disease. Louise J. Lu and Ji Liu. Yale J Biol Med. 2016 Sep; 89(3): 325–330. Published online 2016 Sep 30. PMCID: PMC5045141.


MICROBIOMA E PSIQUIATRIA

The gut microbiota and psychiatric illness. Glenda MacQueen, MD, PhD, Michael Surette, PhD, and Paul Moayyedi, MB, PhD. J Psychiatry Neurosci. 2017 Mar; 42(2): 75–77. doi:  10.1503/jpn.170028.

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. G B Rogers, D J Keating, R L Young, M-L Wong, J Licinio and S Wesseling. Molecular Psychiatry (2016) 21, 738–748; doi:10.1038/mp.2016.50; published online 19 April 2016.

The gut microbiome composition associates with bipolar disorder and illness severity.Simon J. Evans, Christine M. Bassis, Robert Hein, Shervin Assari, Stephanie A. Flowers, Marisa B. Kelly, Vince B. Young, Vicky E. Ellingrod, Melvin G. McInnis. Journal of Psychiatric Research  April 2017Volume 87, Pages 23–29 DOI:10.1016/j.jpsychires.2016.12.007.

Gut–brain axis in 2016: Brain–gut–microbiota axis — mood, metabolism and behavior. Timothy G. Dinan & John F. Cryan. Nature Reviews Gastroenterology & Hepatology 14,69–70 (2017)    doi:10.1038/nrgastro.2016.200 published online    05 January 2017.

Bifidobacterium in the gut microbiota confer resilience to chronic social defeat stress in mice.Chun Yang, Yuko Fujita, Qian Ren, Min Ma, Chao Dong & Kenji Hashimoto. Scientific Reports 7, Article number: 45942 (2017) doi:10.1038/srep45942.

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. G B Rogers, D J Keating, R L Young, M-L Wong, J Licinio and S Wesselingh. Molecular Psychiatry (2016) 21, 738–748; doi:10.1038/mp.2016.50; published online 19 April 2016.


MICROBIOMA E PNEUMOLOGIA

Microbiome effects on immunity, health and disease in the lung. Shakti D Shukla, Kurtis F Budden, Rachael Neal and Philip M Hansbro. Clinical & Translational Immunology (2017) 6, e133; doi:10.1038/cti.2017.6.

The respiratory tract microbiome and lung inflammation: a two-way street. G B Huffnagle, R P Dickson and N W Lukacs. Mucosal Immunology (2017) 10, 299–306; doi:10.1038/mi.2016.108.

Asthma and the microbiome: defining the critical window in early life. Leah T. Stiemsma and Stuart E. Turvey. Allergy, Asthma & Clinical Immunology201713:3. DOI: 10.1186/s13223-016-0173-6.

Airway Microbial Diversity is Inversely Associated with Mite-Sensitized Rhinitis and Asthma in Early Childhood. Chih-Yung Chiu, Yi-Ling Chan, Yu-Shuen Tsai, Ssu-An Chen, Chia-Jung Wang, Kuan-Fu Chen & I.-Fang Chung. Scientific Reports 7, Article number: 1820 (2017) doi:10.1038/s41598-017-02067-7.

The altered gut microbiota in adults with cystic fibrosis. D.G. Burke, F. Fouhy, M. J. Harrison, M. C. Rea, P. D. Cotter, O. O’Sullivan, C. Stanton, C. Hill, F. Shanahan, B. J. Plant and R. P. Ross.BMC MicrobiologyBMC series – open, inclusive and trusted201717:58. https://doi.org/10.1186/s12866-017-0968-8.

The effects of inhaled aztreonam on the cystic fibrosis lung microbiome. Alya A. Heirali, Matthew L. Workentine, Nicole Acosta, Ali Poonja, Douglas G. Storey, Ranjani Somayaji, Harvey R. Rabin, Fiona J. Whelan, Michael G. Surette and Michael D. Parkins.

Microbiome20175:51. https://doi.org/10.1186/s40168-017-0265-7.

The role of the microbiome in exacerbations of chronic lung diseases.

Robert P Dickson, MD, Prof Fernando J Martinez, MD, Prof Gary B Huffnagle.

THE LANCET Volume 384, No. 9944, p691–702, 23 August 2014. DOI: 10.1016/S0140-6736(14)61136-3.

Characterization of microbiome in patients with lung cancer comparing with benign mass-like lesions. Jisoo Choi, Moo Suk Pack, Dong Eun Yong, Ji Yeon Sung, Sang Hoon Lee, Eun Hye Lee, Ji Eun Park, Mi Hwa Shin. European Respiratory Journal 2016 48: PA1208; DOI: 10.1183/13993003.congress-2016.PA1208.


MICROBIOMA E GASTROENTEROLOGIA

Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet? Eamonn M. M. Quigley. Nature Reviews Gastroenterology & Hepatology14, 315–320 (2017) doi:10.1038/nrgastro.2017.29.

Microbiota: Tolerating gluten—a role for gut microbiota in celiac disease? Katrina Ray. Nature Reviews Gastroenterology and Hepatology 9, 242 (May 2012) | doi:10.1038/nrgastro.2012.66.

Dysbiosis and the immune system. Maayan Levy, Aleksandra A. Kolodziejczyk, Christoph A. Thaiss        & Eran Elinav.Nature Reviews Immunology 17,219–232 (2017) doi:10.1038/nri.2017.7.

Biomarkers for the early detection of PDAC(pancreatic ductal adenocarcinoma).Katrina Ray Nature Reviews Gastroenterology & Hepatology 14,504–505(2017)    doi:10.1038/nrgastro.2017.111.

Microbiome and pancreatic cancer: A comprehensive topic review of literature.Natalie Ertz-Archambault, Paul Keim, and Daniel Von Hoff. World J Gastroenterol. 2017 Mar 14; 23(10): 1899–1908. doi:10.3748/wjg.v23.i10.1899.

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Zobair Younossi, Quentin M. Anstee[…]Elisabetta Bugianesi.Nature Reviews Gastroenterology and Hepatology.  2017 Sep 20. doi: 10.1038/nrgastro.2017.109

The gut microbiome and liver cancer: mechanisms and clinical translation. Le-Xing Yu& Robert F. Schwabe. Nature Reviews Gastroenterology & Hepatology14, 527–539 (2017). doi:10.1038/nrgastro.2017.72.

Gastric adenocarcinoma. Jaffer A. Ajani, Jeeyun Lee, Takeshi Sano, Yelena Y. Janjigian, Daiming Fan & Shumei Song. Nature Reviews Disease Primers 3, Article number: 17036 (2017). doi:10.1038/nrdp.2017.36.


MICROBIOMA E DOENÇAS CARDIOVASCULARES

Role of gut microbiota in atherosclerosis. Annika Lindskog Jonsson& Fredrik Bäckhed. Nature Reviews Cardiology 14, 79–87 (2017) doi:10.1038/nrcardio.2016.183.

Gut Microbiota in Cardiovascular Health and Disease. W.H. Wilson Tang, Takeshi Kitai, Stanley L. Hazen. Circulation Research. 2017;120:1183-1196. doi.org/10.1161/CIRCRESAHA.117.309715.

The gut microbiome and cardiovascular risk: current perspective and gaps of knowledge. Yeela Talmor-Barkan& Ran Kornowski.

Future Cardiology Vol. 13, No. 3 | Editorial  31 May 2017https://doi.org/10.2217/fca-2017-0014.The gut microbiome and hypertension. Pevsner-Fischer M, Blacher E, Tatirovsky E, Ben-Dov IZ, Elinav E. Curr Opin Nephrol Hypertens. 2017 Jan;26(1):1-8.

Gut microbiota dysbiosis contributes to the development of hypertension. Jing Li†, Fangqing Zhao†, Yidan Wang†, Junru Chen†, Jie Tao†, Gang Tian, Shouling Wu, Wenbin Liu, Qinghua Cui. Microbiome 20175:14. doi.org/10.1186/s40168-016-0222.

The Gut Microbiome and Its Role in Cardiovascular Diseases.W. H. Wilson Tang, Stanley L. Hazen. Circulation. 2017;135:1008-1010  Originally published March 13, 2017. doi.org/10.1161/CIRCULATIONAHA.116.024251.


MICROBIOMA E DOENÇAS ARTICULARES

Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Scher JU, Ubeda C, Artacho A, Attur M, Isaac S, Reddy SM, Marmon S, Neimann A, Brusca S, Patel T, Manasson J, Pamer EG, Littman DR, Abramson SB. Arthritis Rheumatol 2015; 67:128–139. PMID: 25319745 PMCID: PMC4280348. DOI: 10.1002/art.38892.

Microbiome in Inflammatory Arthritis and Human Rheumatic Diseases. Jose U. Scher, MD, Dan R. Littman, MD, PhD, and Steven B. Abramson, MD. Arthritis Rheumatol. 2016 Jan; 68(1): 35–45. doi: 10.1002/art.39259.

Role of the Gut Microbiome in Modulating Arthritis Progression in Mice. Xiaofei Liu, Benhua Zeng, Juan Zhang, Wenxia Li, Fangxiang Mou, Heng Wang, Qinghua Zou, Bing Zhong, Like Wu, Hong Wei & Yongfei Fang. Scientific Reports 6, Article number: 30594 (2016) doi:10.1038/srep30594.

The Intestinal Microbiome in Spondyloarthritis.Tejpal Gill, PhD, Mark Asquith, PhD, James T. Rosenbaum, MD, and Robert A. Colbert, MD, PhD. Curr Opin Rheumatol. Author manuscript; available in PMC 2016 Jul 1.doi: 10.1097/BOR.0000000000000187.

Gut dysbiosis in ankylosing spondylitis. Caroline Barranco Nature Reviews Rheumatology  11,  1 (2015). doi:10.1038/nrrheum.2014.207.

Regulation of inflammation by microbiota interactions with the host. J Magarian Blander, Randy S Longman, Iliyan D Iliev, Gregory F Sonnenberg and David Artis. Nature Immunology 18,  851–860   (2017). doi:10.1038/ni.3780.


MICROBIOMA E DOENÇAS NEURODEGENERATIVAS

Microbiology: Gut microbes augment neurodegeneration. Daniel Erny & Marco Prinz. Nature 544, 304–305 (20 April 2017). doi:10.1038/nature21910.

Could gut microbiota influence severity of Parkinson disease? Hemi Malkki. Nature Reviews Neurology  13,  66–67  (2017)   doi:10.1038/nrneurol.2016.195.

Parkinson’s disease and Parkinson’s disease medications have distinct signatures of the gut microbiome. Erin M. Hill-Burns, Justine W. Debelius, James T. Morton, William T. Wissemann, Matthew R. Lewis, Zachary D. Wallen, Shyamal D. Peddada, Stewart A. Factor, Eric Molho, Cyrus P. Zabetian, Rob Knight, and Haydeh Payami. Movement Disorders, 2017. doi: 10.1002/mds.26942.

Human gut microbiota: the links with dementia development.Rashad Alkasir. Protein Cell. 2017 Feb; 8(2): 90–102. Published online 2016 Nov 19. doi:  10.1007/s13238-016-0338-6.

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels. Laura Bonfili. Scientific Reports 7, Article number: 2426 (2017) doi:10.1038/s41598-017- 02587-2.

Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer’s disease (AD).Yuhai Zhao and Walter J. Lukiw. Journal of Nature and Science (JNSCI), Vol.1, No.7, e138, 2015.

The microbiome: A key regulator of stress and neuroinflammation. Kieran Reaa and Timothy G.Dinanab. Neurobiology of Stress 4 (2016). doi.org/10.1016/j.ynstr.2016.03.001.

Neurodegeneration: Mechanistic overlap in ALS. Kevin Da Silva.Nature Medicine  20,  714  (2014)  doi:10.1038/nm.3634.

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Jun Chen, Nicholas Chia, Krishna R. Kalari, Janet Z. Yao, Martina Novotna, M. Mateo Paz Soldan, David H. Luckey.Scientific Reports 6, Article number: 28484 (2016) doi:10.1038/srep28484.

Alterations of the human gut microbiome in multiple sclerosis. Sushrut Jangi, Roopali Gandhi, Laura M. Cox, Ning Li, Felipe von Glehn, Raymond Yan, Bonny Patel. Nature Communications 7, Article number: 12015 (2016). doi:10.1038/ncomms12015.

The Gut Microbiome and the Brain. Leo Galland. J Med Food. 2014 Dec 1; 17(12): 1261–1272.  doi:  10.1089/jmf.2014.7000.


MICROBIOMA E DOENÇAS AUTOIMUNES

Dysbiosis and the immune system. Maayan Levy, Aleksandra A. Kolodziejczyk, Christoph A. Thaiss & Eran Elinav. Nature Reviews Immunology  17, 219–232 (2017) doi:10.1038/nri.2017.7. Published online  06 March 2017.

Dietary factors in rheumatic autoimmune diseases: a recipe for therapy? Shani Dahan, Yahel Segal & Yehuda Shoenfeld. Nature Reviews Rheumatology  13,  348–358  (2017). doi:10.1038/nrrheum.2017.42

Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans. Vatanen T et al. Cell 2016 May 5; 165:842. doi.org/10.1016/j.cell.2016.04.007)


MICROBIOMA E AUTISMO

New evidences on the altered gut microbiota in autism spectrum disorders. Francesco Strati, Duccio Cavalieri, Davide Albanese, Claudio De Felice. Microbiome 2017  5:24. doi.org/10.1186/s40168-017-0242-1.

Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Dae-Wook Kang†, James B. Adams†, Ann C. Gregory†, Thomas Borody, Lauren Chittick, Alessio Fasano. Microbiome 2017  5:10. https://doi.org/10.1186/s40168-016-0225-7.

The Gut Microbiota and Autism Spectrum Disorders. Qinrui Li, Ying Han, Angel Belle C. Dy, and Randi J. Hagerman. Front Cell Neurosci. 2017; 11: 120.  Published online 2017 Apr 28. doi:  10.3389/fncel.2017.00120.